s@

"stoutman" <.@.>

04/10/2005 2:40 AM

Woodworking Meets Drug Design

Stumbled on this web page. Pretty cool stuff.

http://www.tamu.edu/biograph/MOS/aspirin.htm


This topic has 18 replies

tt

"tom"

in reply to "stoutman" <.@.> on 04/10/2005 2:40 AM

03/10/2005 9:16 PM

Mmmmm, walnut.....but I still don't understand how aspirin works....
Tom

tt

"tom"

in reply to "stoutman" <.@.> on 04/10/2005 2:40 AM

04/10/2005 7:47 AM

Chicken! Tom

tt

"tom"

in reply to "stoutman" <.@.> on 04/10/2005 2:40 AM

04/10/2005 12:13 PM

Stoutman, I believe Larry was calling me the "turkey". Didn't hurt
none. Tom

tt

"tom"

in reply to "stoutman" <.@.> on 04/10/2005 2:40 AM

04/10/2005 12:16 PM

Or maybe not... Tom

f

in reply to "stoutman" <.@.> on 04/10/2005 2:40 AM

04/10/2005 1:44 PM


stoutman wrote:
> Aspirin inhibits the cyclooxengenase enzymes Cox-1 and Cox-2 which prevent
> the formation of inflammatory prostaglandins.
>
> Aspirin binds to the active site of the enzyme, and irreversibly inhibits
> it, rendering it useless.

How does that reduce fever?

--

FF

tt

"tom"

in reply to "stoutman" <.@.> on 04/10/2005 2:40 AM

04/10/2005 6:11 PM

I think it's some deeply-seated netiquette thing. And I'm sorry I
called you a chicken, Larry. I was confused as to who you were
referring. Top or bottom. Now, Stoutman, you say you're sorry, too, and
maybe Dave'll unplonk you! Top or bottom, really! Off topic. Tom

s@

"stoutman" <.@.>

in reply to "stoutman" <.@.> on 04/10/2005 2:40 AM

05/10/2005 1:16 AM


"tom" <[email protected]> wrote in message
news:[email protected]...
>I think it's some deeply-seated netiquette thing. And I'm sorry I
> called you a chicken, Larry. I was confused as to who you were
> referring. Top or bottom. Now, Stoutman, you say you're sorry, too, and
> maybe Dave'll unplonk you! Top or bottom, really! Off topic. Tom


I will say I'm sorry to Larry for the bovine comment, but Dave has gotta
unplonk me first. :( Otherwise he is gonna have to spend the rest of
the day in "time out".

After all, I'm not sure the bovine comment was even worthy of a PLONK? Was
it really PLONKable?

DH

Dave Hinz

in reply to "stoutman" <.@.> on 04/10/2005 2:40 AM

04/10/2005 4:01 PM

On Tue, 04 Oct 2005 15:53:48 GMT, stoutman <> wrote:
> Your bottom posting corrected bovine!

<plonk>

GG

"George"

in reply to "stoutman" <.@.> on 04/10/2005 2:40 AM

04/10/2005 7:03 AM


"stoutman" <.@.> wrote in message
news:[email protected]...
> Stumbled on this web page. Pretty cool stuff.
>
> http://www.tamu.edu/biograph/MOS/aspirin.htm
>

Friend of mine from Texas - C 130 Navigator - went to A&M in the industrial
arts program. Wonder if the model makers came from IA or the
Pharmacy/Physiology side?

s@

"stoutman" <.@.>

in reply to "stoutman" <.@.> on 04/10/2005 2:40 AM

05/10/2005 12:36 AM

Yeah,

I think it was a "turkey" call in my general direction. I'm a little
confused by the comment. I wasn't offended, just confused...and I get
Plonked???.....which leads to even more confusion...

-Turkey



"tom" <[email protected]> wrote in message
news:[email protected]...
> Or maybe not... Tom
>

s@

"stoutman" <.@.>

in reply to "stoutman" <.@.> on 04/10/2005 2:40 AM

04/10/2005 4:06 PM

Your plonking me when he called me a turkey.

Plonk away.


"Dave Hinz" <[email protected]> wrote in message
news:[email protected]...
> On Tue, 04 Oct 2005 15:53:48 GMT, stoutman <> wrote:
>> Your bottom posting corrected bovine!
>
> <plonk>
>

MB

Mike Berger

in reply to "stoutman" <.@.> on 04/10/2005 2:40 AM

04/10/2005 10:58 AM

I would think it would be very easy to make from a computer
model and 3D laser cutter.

stoutman wrote:
> Aspirin inhibits the cyclooxengenase enzymes Cox-1 and Cox-2 which prevent
> the formation of inflammatory prostaglandins.
>
> Aspirin binds to the active site of the enzyme, and irreversibly inhibits
> it, rendering it useless.
>
> The models, made from wood depict the enzymes active site in 3-D. I have
> never seen anyone make a 3-D model of a protein/enzyme active site from
> wood. Very strange...
>

s@

"stoutman" <.@.>

in reply to "stoutman" <.@.> on 04/10/2005 2:40 AM

04/10/2005 4:42 AM

Aspirin inhibits the cyclooxengenase enzymes Cox-1 and Cox-2 which prevent
the formation of inflammatory prostaglandins.

Aspirin binds to the active site of the enzyme, and irreversibly inhibits
it, rendering it useless.

The models, made from wood depict the enzymes active site in 3-D. I have
never seen anyone make a 3-D model of a protein/enzyme active site from
wood. Very strange...




"tom" <[email protected]> wrote in message
news:[email protected]...
> Mmmmm, walnut.....but I still don't understand how aspirin works....
> Tom
>

b

in reply to "stoutman" <.@.> on 04/10/2005 4:42 AM

04/10/2005 7:04 PM

On 4 Oct 2005 18:11:15 -0700, "tom" <[email protected]> wrote:

>I think it's some deeply-seated netiquette thing. And I'm sorry I
>called you a chicken, Larry. I was confused as to who you were
>referring. Top or bottom. Now, Stoutman, you say you're sorry, too, and
>maybe Dave'll unplonk you! Top or bottom, really! Off topic. Tom


actually, getting plonked by dave hinz is kind of an honor.

s@

"stoutman" <.@.>

in reply to "stoutman" <.@.> on 04/10/2005 2:40 AM

04/10/2005 3:53 PM

Your bottom posting corrected bovine!


> Did you know that aspirin is also a great birth control device?
>
> Usage: The woman holds one firmly between her knees.




"Larry Jaques" <novalidaddress@di\/ersify.com> wrote in message
news:[email protected]...
> On Tue, 04 Oct 2005 04:42:50 GMT, with neither quill nor qualm,
> "stoutman" <.@.> quickly quoth:
>
>>"tom" <[email protected]> wrote in message
>>news:[email protected]...
>>> Mmmmm, walnut.....but I still don't understand how aspirin works....
>
> (your topposting corrected, turkey.)
>
>
>>Aspirin inhibits the cyclooxengenase enzymes Cox-1 and Cox-2 which prevent
>>the formation of inflammatory prostaglandins.
>>
>>Aspirin binds to the active site of the enzyme, and irreversibly inhibits
>>it, rendering it useless.
>>
>>The models, made from wood depict the enzymes active site in 3-D. I have
>>never seen anyone make a 3-D model of a protein/enzyme active site from
>>wood. Very strange...
>
>
>
>
> --------------------------------------------------------
> Murphy was an Optimist
> ----------------------------
> http://diversify.com Comprehensive Website Development

s@

"stoutman" <.@.>

in reply to "stoutman" <.@.> on 04/10/2005 2:40 AM

04/10/2005 11:10 PM

Prostaglandins also induce (in a dose dependent manner) fever by acting in
the CNS.

-



<[email protected]> wrote in message
news:[email protected]...
>
> stoutman wrote:
>> Aspirin inhibits the cyclooxengenase enzymes Cox-1 and Cox-2 which
>> prevent
>> the formation of inflammatory prostaglandins.
>>
>> Aspirin binds to the active site of the enzyme, and irreversibly inhibits
>> it, rendering it useless.
>
> How does that reduce fever?
>
> --
>
> FF
>

LJ

Larry Jaques

in reply to "stoutman" <.@.> on 04/10/2005 2:40 AM

04/10/2005 7:43 AM

On Tue, 04 Oct 2005 04:42:50 GMT, with neither quill nor qualm,
"stoutman" <.@.> quickly quoth:

>"tom" <[email protected]> wrote in message
>news:[email protected]...
>> Mmmmm, walnut.....but I still don't understand how aspirin works....

(your topposting corrected, turkey.)


>Aspirin inhibits the cyclooxengenase enzymes Cox-1 and Cox-2 which prevent
>the formation of inflammatory prostaglandins.
>
>Aspirin binds to the active site of the enzyme, and irreversibly inhibits
>it, rendering it useless.
>
>The models, made from wood depict the enzymes active site in 3-D. I have
>never seen anyone make a 3-D model of a protein/enzyme active site from
>wood. Very strange...

Did you know that aspirin is also a great birth control device?

Usage: The woman holds one firmly between her knees.



--------------------------------------------------------
Murphy was an Optimist
----------------------------
http://diversify.com Comprehensive Website Development

PL

Philip Lewis

in reply to "stoutman" <.@.> on 04/10/2005 2:40 AM

04/10/2005 12:57 PM

Would have been much more appropriate to make it in willow wood.
http://www.google.com/search?q=willow+tree+aspirin

--
be safe.
flip
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